FENUGREEK TREATMENT OF POLYCYSTIC OVARIAN SYNDROME: AN IN-SILICO EVALUATION TO EXPLORE THE THERAPEUTIC EFFICACY OF QUERCETIN

Abstract

Background:
Polycystic ovarian syndrome (PCOS) is a fairly common condition that affects both endocrine and metabolic systems. It affects women of reproductive age of all ethnicity and race. Only a small number of females are diagnosed with it. There is a good percentage of people who are still not diagnosed because of a lack of good diagnostic criteria and varying symptoms among different individuals. Fenugreek is an herb that contains many constituents including Quercetin. It helps in the regulation of steroidogenesis.

Material and Methods:
Molecular docking of Quercetin with insulin receptor substrate 1, folliclestimulating hormone receptor and androgen receptor was performed using Autodock4. The ADME
(absorption, distribution, metabolism and excretion) properties were calculated by using smile notation
in the Swiss ADME web-based tool. The Bioavailability Score was calculated using Mol-inspiration
web-based tool.

Results:
The study shows that Quercetin is having best binding capacity with the androgen receptor
and also shows good binding affinity with FSH receptors and Insulin receptors. This indicates Quercetin
can have a positive effect on PCOS.

Conclusion:
We can conclude that Quercetin is helpful for the treatment of PCOS