NEPHROPROTECTIVE EFFECT OF METHANOLIC EXTRACT OF DINOTHROMBIUM TINCTORIUM IN ALBINO RATS

Abstract

Modern world has proven scientifically that medicines derived from animals are important tools in treating ailments today.

Objective:

In current project, goal was to estimate the nephro-protective effects of methanolic extract of Dinothrombium tinctorium against carbon tetrachloride-induced nephrotoxicity.

Study design:

It was a randomised control study.

Methodology:

Aqueous methanolic extract (70% v/v) of Dinothrombium tinctorium (Dt.Cr) was arranged followed by subsequent evaporations. Renal toxicity was induced by CCl4 (2 ml/kg, p.o) in paraffin oil on 7th day of experiment. Administration of methanolic extract of Dinothrombium tinctorium (300mg/kg body weight/day) orally sheltered the CCl4 caused elevation of renal serum markers that include urea and creatinine. There was renal markers elevation in the CCl4 alone treated animals.

Results:

Administration of methanolic extract to CCl4 encounter protection against the renal toxicity.

Conclusion:

The findings thus suggested that this methanolic extract can be used as nephroprotective agent against CCl4-induced renal toxicity in albino rats.