FREQUENCY OF THROMBOCYTOPENIA AMONG DIFFERENT AGE GROUPS OF PATIENTS WITH LIVER CIRRHOSIS

Abstract

Background:

Patients with cirrhosis frequently exhibit thrombocytopenia, which might prompt an unnecessary referral for a bone marrow biopsy. The frequency of thrombocytopenia in liver cirrhosis is largely unknown in the study area. The main aim of our study is to evaluate the prevalence of thrombocytopenia in such patients in the study area.

Material and Methods:

A retrospective cross-sectional study was conducted on 268 confirmed liver cirrhosis patients for thrombocytopenia in Khyber Teaching Hospital, Peshawar. Both, male and female subjects with established liver cirrhosis were included in the study while Patients had concurrent illnesses which can induce thrombocytopenia like malaria and dengue fever, ITP. This study takes a total of six months duration. Data analysis was done using SPSS software Version 20.

Results:

Results showed that 74.8% of the studied subjects were diagnosed with thrombocytopenia while 25.2% were normal. Thrombocytopenic patients were also categorized into mild, moderate, and severe. Among different age groups, severe thrombocytopenia was found to be highest in all age groups having 113 (42.2%) subjects. Consequently, Severe thrombocytopenia in the age group 51-60 years was diagnosed in 99 (36.9%) cirrhosis patients which is statistically significant with a p-value =0.032. In addition, 56 (20.9%) of the age group 31–40 years age were diagnosed with severe thrombocytopenia.

Conclusion:

Our study concluded that thrombocytopenia showed to be one of the diagnostic parameters while to check for complications, related to liver cirrhosis